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Traditionally, vials or glass parts have already been rendered pyrogen-cost-free by dry warmth sterilization at high temperatures. Some texts have advisable the depyrogenation of glassware and equipment by heating at a temperature of 250 C for forty five minutes.

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There could be a number of resources of pyrogens in parenteral and health care gadget products and solutions. Regular sources are: the water used since the solvent or while in the processing; packaging elements; the substances, raw elements or tools Employed in the preparing in the products.}